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New Study Shows Promise In The Diagnosis of Poor Blood Circulation

Published on: 16 Jul, 2025
Updated on: 16 Jul, 2025

Professor Christian Heiss, who led the study at the University of Surrey

An alternative diagnostic method could improve early detection and treatment of peripheral artery disease (PAD), according to a new study from the University of Surrey.

PAD is a common condition, affecting up to a quarter of adults, that causes poor blood circulation to the legs and feet.

This may result in pain, ulcers, and, most dangerously, in amputation. Often PAD is diagnosed too late.

The study, published in European Heart Journal (Imaging Methods and Practice), looked at finding a more accurate diagnostic measure to what is usually used to diagnose PAD.

One of the methods often used, in people with diabetes in particular, is the toe brachial index (TBI).

TBI is a simple, painless test, in which patients’ blood pressure in their arms is compared to the blood pressure in their toes. By doing this, doctors can tell whether the feet and toes of the patients are getting enough blood flow. However, the test can be unreliable in some people, especially those with diabetes.

Researchers worked with 155 limbs in patients who were undergoing treatment for PAD. The study used a Doppler ultrasound waveform to estimate TBI (eTBI), which provided a faster, more accurate, reproducible, and accessible alternative to the current PAD test. This was found to be more consistent than standard TBI, with different health professionals getting similar results even on different ultrasound machines. The novel method was as good as the standard test at detecting the effectiveness of treatments to improve blood flow.

The head of the study, Professor Christian Heiss, who is Professor of Cardiovascular Medicine at the University of Surrey, said: “This research could lead to earlier diagnosis and more effective management of PAD, especially for people with diabetes and those at higher risk of heart diseases, which could result in preventing serious complications like foot ulcers and amputations.”

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